Next Generation Sequencing (NGS) for the longest time was considered “the future of forensic DNA analysis.” However, it is rapidly becoming a power-ful tool in forensic DNA laboratories today for short tandem repeat (STR) typing, single nucleotide polymorphism (SNP) typing, and mitochondrial DNA. NGS technology can be a game changer for helping to solve crimes, create investigational leads, and solve complex ancestry cases. While cap-illary electrophoresis (CE) remains routine in forensic DNA analysis, the introduction of NGS to the forensic DNA field allows an alternative solution for the analysis of challenging forensic casework samples. In recent years, commercial companies have been releasing ready-to-use chemistries and protocols that can easily be incorporated into existing workflows in forensic DNA laboratories.