Following two decades of tremendous advancements in biomedical research, nanomedicine has now spread from labs to hospital wards and is already starting to redesign the state of the art in clinical practice. Many of the technological advancements achieved to date are offering new unexpected benefits to millions of patients, both in terms of hyperearly diagnosis as well as in terms of regenerative medicine; yet those are excellent premises for an even larger impact on the future of the entire humankind. Many healthcare providers, business leaders, and lawyers are well aware that, in the coming years, medicine will be further implemented by a wide range of novel materials with bioactive and therapeutic properties, rare diseases will be defeated by cell therapy, and tissue engineering will overcome the limits of organ transplantation. Their needs are together similar and multifaceted: some of these professionals are still looking for a comprehensive guide to understand in detail this amazing revolution, some are trying to address new challenges in clinical research, those that will hopefully lead to the next Nobel Prize, and others are stillwondering how to prevent improper use of these innovative technologies by patients.